CRISPR-ENGINEERED THERANOSTIC FOR DRUG-RESISTANT STAPH INFECTIONS
Using Smart Wound Dressing To Treat Without Antibiotics
THE PROBLEM
Drug-resistant Staphylococcus aureus infections, such as MRSA, result from decades of antibiotic overuse. For years, physicians prescribed antibiotics for a wide variety of ailments, many of which were viral infections not affected by the drugs given. Even when used appropriately, antibiotics contribute to the rise of drug-resistant bacteria due to the evolutionary process of surviving germs becoming stronger and overcoming treatments. Infections like MRSA are prevalent in the healthcare setting, such as hospitals and long-term care facilities, where patients are older or dealing with weakened immune systems. Since infections can spread from the bloodstream to major organs and become life-threatening, it is critical to explore new treatment options.
OUR SOLUTION
Researchers at The University of Alabama have developed a smart wound dressing able to detect and eliminate a staphylococcus aureus infection using engineered, genetically-compact phages released from a biocompatible hyaluronic acid hydrogel. This treatment is free of antibiotics. Instead, it relies on integrated phages to search for and destroy the bacterial infection from superficial skin wounds before it can migrate to other areas of the body and cause more severe damage. This integrated system allows for earlier, more efficient treatment that enables patients to be discharged earlier, saving time and money.
THE ADVANTAGES
- Treats infections effectively without antibiotics
- Able to destroy antibiotic-resistant bacteria
- Faster than current methods; uses theranostics to quickly diagnose & treat wounds
- Saves money & time with earlier patient discharges from the hospital
- At-home detection by the patient is possible
- Potential to modify hydrogel to target other pathogens
